Fildena: Potency and Considerations

Characteristic	Details
Active Ingredient	Sildenafil
Available Dosages	25 mg, 50 mg, 100 mg
Form	Tablet
Manufacturer	Fortune Healthcare
Route of Administration	Oral
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Pharmacokinetics of Fildena 100 mg

Fildena, particularly the 100 mg variant, plays a crucial role in enhancing male sexual function. When administered orally, the compound experiences rapid gastrointestinal absorption. It reaches peak plasma concentrations within 30 to 120 minutes. Bioavailability approaches 40%. Food intake can delay absorption, reducing the plasma levels. In systemic circulation, it binds extensively to plasma proteins.

The metabolic pathway of Fildena involves hepatic enzymes, specifically CYP3A4. Its active metabolite retains 50% of its original activity. Elimination primarily occurs via renal excretion, with a minor portion eliminated in feces. The compound’s half-life averages 4 hours, extending its effective duration to 4-6 hours.

Mechanism of Action of Sildenafil 100 mg

Sildenafil 100 mg facilitates penile erection by selectively inhibiting phosphodiesterase type 5 (PDE5). This blockade results in elevated levels of cyclic guanosine monophosphate (cGMP). Enhanced cGMP mediates smooth muscle relaxation in the corpus cavernosum, promoting increased blood flow. The process necessitates sexual stimulation, acting synergistically with nitric oxide (NO) pathways.

The drug’s efficacy lies in its ability to restore erectile function. By targeting the enzymatic degradation of cGMP, Fildena ensures prolonged vasodilation. Its therapeutic action is confined to peripheral tissues, minimizing systemic effects.

Fildena Precautions to Consider

Before initiating therapy with Fildena, consider patient history. Cardiovascular health assessment remains paramount, given potential hypotensive interactions. Fildena is contraindicated in patients using nitrates or nitric oxide donors. Concomitant use with potent CYP3A4 inhibitors may require dose adjustments.

Potential interactions with antihypertensives necessitate careful titration. Assess hepatic and renal function, as these can impact drug clearance. Patients with anatomical penile deformation or predisposition to priapism warrant cautious use.

Optimal Storage for Fildena

Store Fildena tablets at controlled room temperature, away from excess moisture. Maintain a stable environment between 15°C and 30°C. Avoid direct sunlight exposure. Keep the medication in its original packaging to protect from light.

Ensure storage away from children and pets. Discard expired tablets responsibly. Do not use beyond the expiry date to prevent diminished efficacy and potential adverse effects.

Recognizing Overdose Signs and Symptoms

Overdose may manifest through pronounced hypotension, dizziness, or syncope. Prolonged erections, or priapism, demand immediate intervention to prevent permanent damage. Tachycardia, nausea, and visual disturbances may also occur.

Seek urgent medical attention if overdose is suspected. Supportive treatment may involve symptomatic management and monitoring vital signs. Hemodialysis may not significantly enhance clearance due to extensive protein binding.

Where to Find Fildena Online

Fildena is available through numerous online platforms. Verify the credibility of suppliers to ensure authenticity. Licensed pharmacies offer a reliable source. Secure transactions are critical for privacy.

Online resources offer convenience and discretion. Be cautious of counterfeit products. Ensure compliance with regional regulations regarding prescription requirements. Access to genuine Fildena facilitates effective management of erectile dysfunction.

Aspect	Details
Active Duration	4-6 hours
Protein Binding	High

Primary source:

• https://www.911mg.org/mens-health/finast.htm
• https://www.iaomc.org/conf.htm
• https://www.imedix.com/drugs/generic-cialis-black/
• https://www.911mg.org/questions-and-answers/erection-problems/ed-after-a-weight-loss-diet-increase-side-effects-of-the-drug.htm
• https://www.vetbehaviorconsults.com/
• https://tadalift.net/andrology/genital-herpes-possible-hazards-and-treatment-options/
• https://www.911mg.org/erectile-dysfunction/silagra.htm
• https://www.911mg.org/erectile-dysfunction/erectafil.htm
• https://www.iaomc.org/ImprovingFutureofMed.pdf